Coaxial electrospinning, in which a concentric spinneret can accommodate two liquids, is regarded as one of the most significant breakthroughs in this area. Keywords: modified coaxial electrospinning core-shell nanofibers dual drug release Teflon-coated spinneret tunable doseĮlectrospinning, a simple and straightforward top-down process for generating nanofibers, has drawn increasing attentions due to easy implementation, capability of treating a variety of materials, convenience in obtaining composites of multiple components and a wide variety potential applications of the resultant nanofibers. The modified coaxial electrospinning is a useful tool to generate nanostructures with a tailored components and compositions in their different parts, and thus to realize the desired functional performances. The results from the in vitro dissolution tests demonstrated that the core-shell nanofibers were able to furnish the desired dual drug controlled-release profiles with a tunable drug release amount in the second phase. APAP was amorphously distributed in the shell and core polymer matrices due to the favorite second-order interactions, as indicated by the X-ray diffraction and FTIR spectroscopic tests. The resultant nanofibers had linear morphologies and clear core-shell structures, as observed by the scanning and transmission electron microscopic images. The Teflon-coated concentric spinneret may facilitate the efficacious and stable preparation of core-shell nanofibers through the modified coaxial electrospinning, where the core fluids were electrospinnable and the shell fluid had no electrospinnability.
Poly(vinyl pyrrolidone) and ethyl cellulose were used as the shell and core polymer matrices respectively, and the content of active ingredient acetaminophen (APAP) in the core was programmed. The core-shell nanofibers were fabricated through a modified coaxial electrospinning using a Teflon-coated concentric spinneret. Received: 19 November 2013 in revised form: 26 December 2013 /Accepted: 27 December 2013 / Published: 8 January 2014Ībstract: This study reports a new type of drug-loaded core-shell nanofibers capable of providing dual controlled release with tunable dose in the second phase. Wei Qian Deng-Guang Yu Ying Li Yao-Zu Liao 2, Xia Wang and Lu Wang 1ġ School of Materials Science & Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China E-Mails: (W.Q.) (Y.L.) (L.W.)Ģ School of Chemistry, University of Bristol, Bristol BS8 1TS, UK E-Mail: Authors to whom correspondence should be addressed E-Mails: (D.-G.Y.) (X.W.) Tel.: +86-21-5527-4069 (D.-G.Y. 2014, 15, 774-786 doi:10.3390/ijms15010774ĭual Drug Release Electrospun Core-Shell Nanofibers with Tunable Dose in the Second Phase
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